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Publications

Research and Review Papers

  1. Ogaili RH, Alassal A, Za'aba NF, Zulkiflee I, Mohd Isa IL. Regenerative strategies for intervertebral disc degeneration. J Orthop Translat. 2025 Jul 4;53:286-308. doi: 10.1016/j.jot.2025.06.003.

  2. Rusli N, Tan JK, Makpol S, Mohd Isa IL, Hakimi NH, Ab Rani N, Remli R. Exploring the Effects of Palm Tocotrienol-Rich Fraction in Diabetic Peripheral Neuropathy Rat’s Model: An Untargeted Metabolomic Profiling and Correlation Study. International Journal of Molecular Sciences. 2025; 26(23):11247. https://doi.org/10.3390/ijms262311247

  3. Nurul Fariha Za Aba, Rusydi Razak, Izzat Zulkiflee, Ahmad Hafiz Kamarrudin, Muhamad Nazrin Mustafa, Kieran Joyce, Raed H Ogaili, Mwafaq Kmail, Fairus Ahmad, Elvy Suhana Mohd Ramli, Sabarul Afian Mokhtar, Isma Liza Mohd Isa. Human Cadaveric Spine Dissection: A Protocol for Harvesting Lumbar Intervertebral Discs from Body Donors. Annals of Anatomy. 2025;260:152680. doi: 10.1016/j.aanat.2025.152680

  4. N. F. Zàaba, R. H. Ogaili, F. Ahmad, I. L. Mohd Isa. Neuroinflammation and nociception in intervertebral disc degeneration: a review of precision medicine perspective. The Spine Journal, 2025, 25(6):1139-1153. https://doi.org/10.1016/j.spinee.2024.12.033

  5. M. Kmail, R. Razak, I. L. Mohd Isa. Engineering Extracellular Matrix-Based Hydrogels for Intervertebral Disc Regeneration. Front. Bioeng. Biotechnol. 2025, 13: 1601154. doi: 10.3389/fbioe.2025.1601154 

  6. R. H. Ogaili, E. S. Mohd Ramli, I. L. Mohd Isa. Isolation, Proliferation, and Identification of Human Wharton’s Jelly Mesenchymal Stem Cells (hWJMSCs). Academic International Journal of Pure Science. 2025, 03(1):18-27

  7. Mohd Razak, R., Harizal, N. A. A., Azman, M. A. Z., Mohd Redzuan, N. S., Ogaili, R. H., Kamarrudin, A. H., Mohamad Azmi, M. F., Kamaruddin, N. A., Abdul Jamil, A. S., Mokhtar, S. A., I. L. Mohd Isa. Deciphering the Effect of Hyaluronic Acid/Collagen Hydrogel for Pain Relief and Tissue Hydration in a Rat Model of Intervertebral Disc Degeneration. Polymers, 2024, 16(18):2574. https://doi.org/10.3390/polym16182574

  8. N. Rusli, C.F. Ng, S. Makpol, Y.P. Wong, I. L. Mohd Isa, R. Remli. Antioxidant Effect in Diabetic Peripheral Neuropathy in Rat Model: A Systematic Review. Antioxidants, 2024, 13(9):1041. https://doi.org/10.3390/antiox13091041

  9. I. L. Mohd Isa, I. Zulkiflee, R. H. Ogaili, N. H. Mohd Yusoff, N. N. Sahruddin, S. R. Sapri, E. S. Mohd Ramli, M. B. Fauzi, S. A. Mokhtar. Three-dimensional Hydrogel with Human Wharton Jelly-1 derived Mesenchymal Stem Cells Towards Nucleus Pulposus Niche. Frontiers in Bioengineering and Biotechnology. 2023, 12(11):1296531. https://doi.org/10.3389/fbioe.2023.1296531

  10. N. G. Kotla, I. L. Mohd Isa, Aitor Larrañaga, Balaji Maddiboyina, Samantha K. Swamy, Gandhi Sivaraman, Praveen K. Vemula. Hyaluronic acid-based bioconjugate systems, scaffolds and their therapeutic potential. Advanced Healthcare Materials. 2023, 12(20): e2203104. https://doi.org/10.1002/adhm.202203104

  11. I. L. Mohd Isa, Seong Lin Teoh, Nurul Huda Mohd Nor, Sabarul Afian Mokhtar. Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration. International Journal of Molecular Sciences, 2023, 24: 208. https://doi.org/10.3390/ijms24010208

  12. I. L. Mohd Isa, S. A. Mokhtar, S. A. Abbah, M. B. Fauzi, A. Devitt, A. Pandit. Intervertebral Disc Degeneration - Biomaterials and Tissue Engineering Strategies Toward Precision Medicine. Advanced Healthcare Materials. 2022, 11, 13: 2102530. https://doi.org/10.1002/adhm.202102530

Conference Proceedings

  1. Zulkiflee I, Daly A, Pandit A, Isa ILM. Development Of Human Disc-On-A-Chip For Intervertebral Disc Using Microfluidic And Hydrogel Systems. Orthopaedic Proceedings, 2025;107-B(SUPP_9):57-57. doi:10.1302/1358-992X.2025.9.057

  2. Mohd Isa IL Isma Liza Mohd Isa, Raed H. Ogaili, Laura O’Flaherty, Elvy Suhana Mohd Ramli, Aminatul Saadiah A. Jamil, Sabarul A. Mokhtar. Hydrogel and stem cell-based approaches for intervertebral disc regeneration and pain modulation. (2025), Abstract. Anat Sci Educ, 18: S1-S77. https://doi.org/10.1002/ase.70141

  3. Mwafaq Kmail, Izzat Zulkiflee, Rasyidah Rehir, Sibylle Grad, I. L. Mohd Isa. ISO10993-Compliant Injectable Collagen-Based Hydrogel For Intervertebral Disc Regeneration: Pre-Clinical Safety And Efficacy Studies. 8th IASCBC & 3rd MAAC, Kuala Lumpur, 13th - 15th August 2025, (2025), Abstract. Anat Sci Educ, 18: S1-S77. https://doi.org/10.1002/ase.70141

  4. I. L. Mohd Isa. Painful Intervertebral Disc Degeneration: Hydrogel System And Disc-On-A-Chip Through Precision Medicine. 21st Congress of the International Federation of Associations of Anatomists, Gwangju, Korea, 5th - 8th Sep 2024. Anatomy & Cell Biology, 2024, Vol. 57, No. 3 Supplement Https://Doi.Org/10.5115/Acbifaa2024.

  5. Nurul Fariha Za'aba, Izzat Zulkiflee, Ahmad Hafiz Kamaruddin, Muhamad Nazrin Mustafa, Kieran Joyce, Fairus Ahmad, Sabarul Afian Mokhtar, I. L. Mohd Isa. Protocol Of Cadaveric Spine Dissection On Body Donors For Harvesting Lumbar Intervertebral Discs. 21st Congress of the International Federation of Associations of Anatomists, Gwangju, Korea, 5th - 8th Sep 2024. Anatomy & Cell Biology, 2024, Vol. 57, No. 3 Supplement Https://Doi.Org/10.5115/Acbifaa2024

  6. Raed Ogaili, Ahmad Hafiz Kamarrudin, Aminatul Saadiah Abdul Jamil, Muhammad Fakhrullah Mohamad Azmi, Nur Aqilah, Kamaruddin, Elvy Suhana Mohd Ramli, Sabarul Afian Mokhtar, I. L. Mohd Isa. Mesenchymal Stem Cell-Encapsulated Hydrogel For Intervertebral Disc Regeneration. 21st Congress of the International Federation of Associations of Anatomists, Gwangju, Korea, 5th - 8th Sep 2024. Anatomy & Cell Biology, 2024, Vol. 57, No. 3 Supplement Https://Doi.Org/10.5115/Acbifaa2024

  7. Izzat Zulkiflee, Omar Konswah, Andrew Daly, Abhay Pandit, I. L. Mohd Isa. Development Of Disc-On-A-Chip Model Using Microfluidic And Hydrogel System. 21st Congress of the International Federation of Associations of Anatomists, Gwangju, Korea, 5th - 8th Sep 2024. Anatomy & Cell Biology, 2024, Vol. 57, No. 3 Supplement Https://Doi.Org/10.5115/Acbifaa2024

  8. Raed Ogaili, I. L. Mohd Isa. Mesenchymal Stem Cell-Encapsulated Hydrogels Alleviate Mechanical Allodynia And Promote Tissue Hydration In A Rat Model Of Intervertebral Disc Injury. 21st Congress of the International Federation of Associations of Anatomists, Gwangju, Korea, 5th - 8th Sep 2024. Anatomy & Cell Biology, 2024, Vol. 57, No. 3 Supplement Https://Doi.Org/10.5115/Acbifaa2024

  9. I. L. Mohd Isa, Mh Busra Fauzi, Nurul Huda Mohd Yusoff, Natasya Nadia Sahruddin,Shaiful Ridzwan Sapri, Mohd Hanafi Damanhuri, Sabarul Afian Mokhtar. The development of hyaluronic acid/collagen-based hydrogel towards the nucleus pulposus niche in facilitating stem cell transplantation to modulate pain. The International Combined Orthopaedic Research Societies (ICORS), World Congress of Orthopaedic Research, Edinburgh, Scotland, 7–9 September 2022. Oral presentation. Orthopaedic Proceedings, 2022, 105-B, No. SUPP_9, pages 18 - 18, https://doi.org/10.1302/1358-992X.2023.9.018

  10. I. L. Mohd Isa, Mh Busra Fauzi, Nurul Huda Mohd Yusoff, Natasya Nadia Sahruddin,Shaiful Ridzwan Sapri, Mohd Hanafi Damanhuri, Sabarul Afian Mokhtar. Hyaluronic Acid/Collagen Hydrogel to Mimic Nucleus Pulposus Microenvironment: An Implication for the Stem Cell Transplantation in Intervertebral Disc. Malaysian Anatomical Association Conference, Johor Bahru, Malaysia, 2-3 Nov 2022. Oral Presentation. Malaysian Journal of Medicine and Health Sciences, 2022, 18, 22

  11. I. L. Mohd Isa, M. B. Fauzi, S. A. Mokhtar. Bioengineering of Human Wharton’s Jelly Derived Mesenchymal Stem Cells on Hyaluronic Acid/Collagen-based Hydrogel Towards Nucleus Pulposus Niche. Annual Meeting of the Orthopaedic Research Society, Tampa, Florida, USA, February 2022. Poster Presentation.

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