top of page

Publications

Research and Review Papers

  1. Ogaili RH, Alassal A, Za'aba NF, Zulkiflee I, Mohd Isa IL. Regenerative strategies for intervertebral disc degeneration. J Orthop Translat. 2025 Jul 4;53:286-308. doi: 10.1016/j.jot.2025.06.003.

  2. Rusli N, Tan JK, Makpol S, Mohd Isa IL, Hakimi NH, Ab Rani N, Remli R. Exploring the Effects of Palm Tocotrienol-Rich Fraction in Diabetic Peripheral Neuropathy Rat's Model: An Untargeted Metabolomic Profiling and Correlation Study. Int J Mol Sci. 2025 Nov 21;26(23):11247. doi: 10.3390/ijms262311247.

  3. Zàaba NF, Razak R, Zulkiflee I, Kamarrudin AH, Mustafa MN, Joyce K, Ogaili RH, Kmail M, Ahmad F, Mohd Ramli ES, Mokhtar SA, Mohd Isa IL. Human cadaveric spine dissection: A protocol for harvesting lumbar intervertebral discs from body donors. Ann Anat. 2025 Jun;260:152680. doi: 10.1016/j.aanat.2025.152680.

  4. Zàaba NF, Ogaili RH, Ahmad F, Mohd Isa IL. Neuroinflammation and nociception in intervertebral disc degeneration: a review of precision medicine perspective. Spine J. 2025 Jun;25(6):1139-1153. doi: 10.1016/j.spinee.2024.12.033.

  5. Kmail M, Razak R, Mohd Isa IL. Engineering extracellular matrix-based hydrogels for intervertebral disc regeneration. Front Bioeng Biotechnol. 2025 May 1;13:1601154. doi: 10.3389/fbioe.2025.1601154. 

  6. Abdul Rahman A, Mohd Isa IL, Biggs MJ, Pandit A. Diatom-Based Artificial Antigen-Presenting Cells: A Novel Approach for Adaptive Immune Modulation. ACS Appl Mater Interfaces. 2025 Jul 2;17(26):37718-37734. doi: 10.1021/acsami.5c07766.

  7. Abdul Rahman A, Mohd Isa IL, Tofail SAM, Bartlomiej L, Rodriguez BJ, Biggs MJ, Pandit A. Modification of Living Diatom, Thalassiosira weissflogii, with a Calcium Precursor through a Calcium Uptake Mechanism: A Next Generation Biomaterial for Advanced Delivery Systems. ACS Appl Bio Mater. 2024 Jun 17;7(6):4102-4115. doi: 10.1021/acsabm.4c00431.

  8. Mohd Razak R, Harizal NAA, Azman MAZ, Mohd Redzuan NS, Ogaili RH, Kamarrudin AH, Mohamad Azmi MF, Kamaruddin NA, Abdul Jamil AS, Mokhtar SA, Mohd Isa IL. Deciphering the Effect of Hyaluronic Acid/Collagen Hydrogel for Pain Relief and Tissue Hydration in a Rat Model of Intervertebral Disc Degeneration. Polymers (Basel). 2024 Sep 11;16(18):2574. doi: 10.3390/polym16182574.

  9. Rusli N, Ng CF, Makpol S, Wong YP, Mohd Isa IL, Remli R. Antioxidant Effect in Diabetic Peripheral Neuropathy in Rat Model: A Systematic Review. Antioxidants (Basel). 2024 Aug 28;13(9):1041. doi: 10.3390/antiox13091041.

  10. Mohd Isa IL, Zulkiflee I, Ogaili RH, Mohd Yusoff NH, Sahruddin NN, Sapri SR, Mohd Ramli ES, Fauzi MB, Mokhtar SA. Three-dimensional hydrogel with human Wharton jelly-derived mesenchymal stem cells towards nucleus pulposus niche. Front Bioeng Biotechnol. 2023 Dec 12;11:1296531. doi: 10.3389/fbioe.2023.1296531.

  11. Kotla NG, Mohd Isa IL, Larrañaga A, Maddiboyina B, Swamy SK, Sivaraman G, Vemula PK. Hyaluronic Acid-Based Bioconjugate Systems, Scaffolds, and Their Therapeutic Potential. Adv Healthc Mater. 2023 Aug;12(20):e2203104. doi: 10.1002/adhm.202203104.

  12. Mohd Isa IL, Teoh SL, Mohd Nor NH, Mokhtar SA. Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration. Int J Mol Sci. 2022 Dec 22;24(1):208. doi: 10.3390/ijms24010208.

  13. Mohd Isa IL, Mokhtar SA, Abbah SA, Fauzi MB, Devitt A, Pandit A. Intervertebral Disc Degeneration: Biomaterials and Tissue Engineering Strategies toward Precision Medicine. Adv Healthc Mater. 2022 Jul;11(13):e2102530. doi: 10.1002/adhm.202102530.

Conference Proceedings

  1. Zulkiflee I, Daly A, Pandit A, Isa ILM. Development Of Human Disc-On-A-Chip For Intervertebral Disc Using Microfluidic And Hydrogel Systems. Orthopaedic Proceedings, 2025;107-B(SUPP_9):57-57. doi:10.1302/1358-992X.2025.9.057

  2. Mohd Isa IL Isma Liza Mohd Isa, Raed H. Ogaili, Laura O’Flaherty, Elvy Suhana Mohd Ramli, Aminatul Saadiah A. Jamil, Sabarul A. Mokhtar. Hydrogel and stem cell-based approaches for intervertebral disc regeneration and pain modulation. (2025), Abstract. Anat Sci Educ, 18: S1-S77. https://doi.org/10.1002/ase.70141

  3. Mwafaq Kmail, Izzat Zulkiflee, Rasyidah Rehir, Sibylle Grad, I. L. Mohd Isa. ISO10993-Compliant Injectable Collagen-Based Hydrogel For Intervertebral Disc Regeneration: Pre-Clinical Safety And Efficacy Studies. 8th IASCBC & 3rd MAAC, Kuala Lumpur, 13th - 15th August 2025, (2025), Abstract. Anat Sci Educ, 18: S1-S77. https://doi.org/10.1002/ase.70141

  4. I. L. Mohd Isa. Painful Intervertebral Disc Degeneration: Hydrogel System And Disc-On-A-Chip Through Precision Medicine. 21st Congress of the International Federation of Associations of Anatomists, Gwangju, Korea, 5th - 8th Sep 2024. Anatomy & Cell Biology, 2024, Vol. 57, No. 3 Supplement Https://Doi.Org/10.5115/Acbifaa2024.

  5. Nurul Fariha Za'aba, Izzat Zulkiflee, Ahmad Hafiz Kamaruddin, Muhamad Nazrin Mustafa, Kieran Joyce, Fairus Ahmad, Sabarul Afian Mokhtar, I. L. Mohd Isa. Protocol Of Cadaveric Spine Dissection On Body Donors For Harvesting Lumbar Intervertebral Discs. 21st Congress of the International Federation of Associations of Anatomists, Gwangju, Korea, 5th - 8th Sep 2024. Anatomy & Cell Biology, 2024, Vol. 57, No. 3 Supplement Https://Doi.Org/10.5115/Acbifaa2024

  6. Raed Ogaili, Ahmad Hafiz Kamarrudin, Aminatul Saadiah Abdul Jamil, Muhammad Fakhrullah Mohamad Azmi, Nur Aqilah, Kamaruddin, Elvy Suhana Mohd Ramli, Sabarul Afian Mokhtar, I. L. Mohd Isa. Mesenchymal Stem Cell-Encapsulated Hydrogel For Intervertebral Disc Regeneration. 21st Congress of the International Federation of Associations of Anatomists, Gwangju, Korea, 5th - 8th Sep 2024. Anatomy & Cell Biology, 2024, Vol. 57, No. 3 Supplement Https://Doi.Org/10.5115/Acbifaa2024

  7. Izzat Zulkiflee, Omar Konswah, Andrew Daly, Abhay Pandit, I. L. Mohd Isa. Development Of Disc-On-A-Chip Model Using Microfluidic And Hydrogel System. 21st Congress of the International Federation of Associations of Anatomists, Gwangju, Korea, 5th - 8th Sep 2024. Anatomy & Cell Biology, 2024, Vol. 57, No. 3 Supplement Https://Doi.Org/10.5115/Acbifaa2024

  8. Raed Ogaili, I. L. Mohd Isa. Mesenchymal Stem Cell-Encapsulated Hydrogels Alleviate Mechanical Allodynia And Promote Tissue Hydration In A Rat Model Of Intervertebral Disc Injury. 21st Congress of the International Federation of Associations of Anatomists, Gwangju, Korea, 5th - 8th Sep 2024. Anatomy & Cell Biology, 2024, Vol. 57, No. 3 Supplement Https://Doi.Org/10.5115/Acbifaa2024

  9. I. L. Mohd Isa, Mh Busra Fauzi, Nurul Huda Mohd Yusoff, Natasya Nadia Sahruddin,Shaiful Ridzwan Sapri, Mohd Hanafi Damanhuri, Sabarul Afian Mokhtar. The development of hyaluronic acid/collagen-based hydrogel towards the nucleus pulposus niche in facilitating stem cell transplantation to modulate pain. The International Combined Orthopaedic Research Societies (ICORS), World Congress of Orthopaedic Research, Edinburgh, Scotland, 7–9 September 2022. Oral presentation. Orthopaedic Proceedings, 2022, 105-B, No. SUPP_9, pages 18 - 18, https://doi.org/10.1302/1358-992X.2023.9.018

  10. I. L. Mohd Isa, Mh Busra Fauzi, Nurul Huda Mohd Yusoff, Natasya Nadia Sahruddin,Shaiful Ridzwan Sapri, Mohd Hanafi Damanhuri, Sabarul Afian Mokhtar. Hyaluronic Acid/Collagen Hydrogel to Mimic Nucleus Pulposus Microenvironment: An Implication for the Stem Cell Transplantation in Intervertebral Disc. Malaysian Anatomical Association Conference, Johor Bahru, Malaysia, 2-3 Nov 2022. Oral Presentation. Malaysian Journal of Medicine and Health Sciences, 2022, 18, 22

  11. I. L. Mohd Isa, M. B. Fauzi, S. A. Mokhtar. Bioengineering of Human Wharton’s Jelly Derived Mesenchymal Stem Cells on Hyaluronic Acid/Collagen-based Hydrogel Towards Nucleus Pulposus Niche. Annual Meeting of the Orthopaedic Research Society, Tampa, Florida, USA, February 2022. Poster Presentation.

bottom of page